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Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: results of an early phase II clinical trial

Since NLRP3 inflammasome activation induces pyroptosis, characterized by cell membrane rupture and the release of intracellular contents such as lactate dehydrogenase (LDH), and this process occurs independently of LPS-stimulated IL-1 transcription, we examined pyroptosis

Front Immunol (2019) 10:1587

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doi: 10.3390/vaccines11121769 183 KennyGMcCannKOBrienCOBroinCTinagoWYousifOet al